What are spherical nucleic acids (SNAs)? What do they consist of and how do they differ from linear nucleic acids? Spherical nucleic acids are structures that are made by taking a nanoparticle ...
Endosomal and cytosolic nucleic acid receptors sense microbial nucleic acids and initiate innate immune responses. However, in some circumstances their activation by endogenous nucleic acids can also ...
DNA hybridization thermodynamics is critical for accurate design of oligonucleotides for biotechnology and nanotechnology applications, but parameters currently in use are inaccurately extrapolated ...
Gastrointestinal (GI) cancers remain a major global health burden, accounting for substantial cancer-related morbidity and mortality worldwide. Cell-free ...
DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...
Some biologists have long hoped that small pieces of RNA that silence genes could help wipe out genetic diseases. But developing nucleic acid medications with good drug properties, such as selectivity ...
The chemical origin of life on Earth is a puzzle that scientists have been trying to piece together for decades. Many hypotheses have been proposed to explain how life came to be and what chemical and ...
Nucleic acids such as DNA and RNA play a central role in gene therapies and vaccines. They store and transmit biological ...
The research focus of the Müller group is the bioinorganic chemistry of nucleic acids with a particular emphasis on the generation, characterization as well as application of nucleic acids including ...
Nucleic acid-based therapeutics such as mRNA, small interfering ribonucleic acid (siRNA) and antisense oligonucleotides (ASOs) represent a groundbreaking approach in medicine, leveraging the power of ...
Quantification of nucleic acid concentrations is often performed by measuring light absorption in UV-VIS spectrometers. There are a few challenges faced in this measurement method. In UV-VIS ...
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